Pyridinecarboxylic acids are active in the metabolism of body. For example,
nicotinic acid (3-pyridinecarboxylic acid) is is a constituent of the redox
coenzymes nicotinamide adenine dinucleotide and nicotinamide adenine
dinucleotide phosphate which are essential in energy metabolism in the
living cell. Pyridinecarboxylic
acids act as chelating agents of elements such as chromium, zinc, manganese,
copper, iron, and molybdenum in the body. They are involved in phenylalanine,
tryptophan, and alkaloids production, and for the quantitative detection of
calcium. This forms a complex with zinc, may facilitate the passage of zinc
through the gastrointestinal wall and into the circulatory system. Nicotinic
acid reacts with hemoglobin and myoglobin, which provide an application in meat
processing to form brighter colour. It acts to reduce plasma cholesterol, as a
vasodilator and to treat pellagra. It is used for the prophylaxis.
Pyridinecarboxylic acids and their derivatives can be studied for these
effects. They used as intermediate to produce pharmaceuticals and metal salts
for the application of nutritional supplements. Quinolinic acid inhibits glucose
synthesis. Fusaric acid (butyl ester of picolinic acid) inhibits dopamine
beta-hydroxylase activity.
- Nicotinic acid (Niacin;
3-Pyridinecarboxylic acid, CAS #: 59-67-6)
- Isonicotinic acid
(4-Pyridinecarboxylic acid, CAS# : 55-22-1)
- Picolinic acid
(2-Pyridinecarboxylic acid; 98-98-6)
- Fusaric acid
(5-Butyl-2-pyridinecarboxylic acid, 536-69-6)
- Dinicotinic acid
(3,5-Pyridinedicarboxylic acid, 499-81-0)
- Dipicolinic acid
(2,6-Pyridinedicarboxylic acid, 499-83-2)
- Quinolinic acid
(2,3-Pyridinedicarboxylic acid, 89-00-9)
- Lutidinic acid
(2,4-Pyridinedicarboxylic acid, 499-80-9)
- Cinchomeronic acid
(3,4-Pyridinedicarboxylic acid, 490-11-9)
- Isocinchomeronic acid
(2,5-Pyridinedicarboxylic acid, 100-26-5)
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